Nonmem software9/24/2023 Media includes a DOS script for installing on Windows and a shell script for installing on UNIX. As bugs are discovered, remedies are reported on the help list, to be implemented by hand. Such manual interventions are tedious, and lack the sort of documentation increasingly expected in a federally regulated industry. NMQual is a perl script (with related utilities) that simplifies installation and maintenance of NONMEM. In particular, configuration details and bug fix details are prespecified in XML files. Installation and operation of NMQual-mediated NONMEM installations generate XML logs for traceability. The macro is designed for hierarchical nonlinear mixed effects models. NMQual is an active, open-source project of Metrum Research Group. The program invokes part of the code contained in the SAS/NLINMIX macro developed by SAS Technical Support and can be considered as an interface for the NLINMIX macro to SAS/IML. The NONMEM® program The NONMEM® program itself is a very general (non-interactive) model analysis program that can be used to fit models to many different types of data. The macro runs under SAS system and is an attractive alternative to NONMEM software.
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